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NOD.Cg-Prkdcscid/J
Strain number : 001303
Common Name: NOD scid mice, NOD SCID mice
- Mice homozygous for the severe combined immune deficiency spontaneous mutation Prkdcscid, commonly referred to as scid, are characterized by an absence of functional T cells and B cells, lymphopenia, hypogammaglobulinemia, and a normal hematopoietic microenvironment.
- Prkdcscid mice accept allogeneic and xenogeneic grafts making them an ideal model for cell transfer experiments.
- Some scid mice will spontaneously develop partial immune reactivity.
- scid mice that have serum Ig levels greater than 1 ug/ml are considered "leaky". scid leakiness is highly strain dependent, increases with age, and is higher in mice housed under non-SPF conditions. In general, Prkdcscid leakiness is low on the NOD/ShiLtSz genetic background.
- Scid mice carry a DNA repair defect and a defect in the rearrangement of genes that code for antigen-specific receptors on lymphocytes.
- Thymic lymphomas occur with high frequency in this strain.
- The life span is typically limited to only 8.5 months under specific pathogen-free conditions.
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