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C57BL/6J
Strain number : 000664
Common Name: C57 mice, B6 mice
- C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced.
- C57BL/6J was the DNA source for the international collaboration that generated the first high quality draft sequence of the mouse genome.
- They are commonly used in the production of transgenic mice.
- They breed well, are long-lived, and have a low susceptibility to tumours.
- It is commonly used as a general-purpose strain and background strain for the generation of congenics carrying both spontaneous and induced mutations.
- Although this strain is refractory to many tumours, it is a permissive background for maximal expression of most mutations.
- C57BL/6J mice are used in a wide variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research.
- This mice strain is resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis.
- Macrophages from this strain are resistant to the effects of anthrax lethal toxin.
Body Weight Information
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